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This is a scientific commentary of the paper ‘Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal-dominant Alzheimer’s disease’, by Rodriguez-Vieitez et al. (doi: 10.1093/brain/awv404 ). Professors Schott and Fox indicate that the featured study demonstrates the importance of inflammatory changes very early in AD pathogenesis and that biomarkers reflecting different aspects of the pathogenic process have diverging trajectories thereafter.

Original publication

DOI

10.1093/brain/awv404

Type

Journal article

Publication Date

03/2016

Volume

139

Pages

922 - 936

Addresses

https://academic.oup.com/brain/article/139/3/922/2468796

Keywords

astrocytosis, autosomal dominant Alzheimer’s disease, , 11 C-deuterium-L-deprenyl , , 18 F-fluorodeoxyglucose , , 11 C-Pittsburgh compound B, alzheimer's disease , mutation , gliosis , minimal cognitive impairment