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Identification of biomarkers for pre-clinical or very early disease for use in experimental medicine is the key challenge to be overcome for the successful and effective delivery of clinical trials in AD. The MRC/NIHR funded Deep and Frequent Phenotyping study is embedded in Dementias Platform UK and will combine established markers, such as PET amyloid imaging and structural MRI, with novel markers, such as PET tau imaging and retinal imaging; and include potential markers which are not yet fully validated in this population, such as electrophysiology and peripheral molecular markers. These potential markers will be evaluated alone and together with conventional assessments of clinical and cognitive change, allowing the development of a multimodal marker set for measurement of change and its prevention or modification in AD.


DPUK final report