White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
Miguel Ángel Araque Caballero , Marc Suárez-Calvet , Marco Duering , Nicolai Franzmeier, Tammie Benzinger , Anne M Fagan , Randall J Bateman , Clifford R Jack , Johannes Levin, Martin Dichgans , Mathias Jucker , Celeste Karch , Colin L Masters , John C Morris, Michael Weiner , Martin Rossor, Nick C Fox , Jae-Hong Lee, Stephen Salloway, Adrian Danek, Alison Goate , Igor Yakushev , Jason Hassenstab, Peter R Schofield, Christian Haass , Michael Ewers
The major goal of this study was to close the research gap of the integration of white matter changes within standard biomarker models of the pathological cascade in Alzheimer’s disease and determine the regional patterns of microstructural white matter alterations in different stages of Alzheimer’s disease.