Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development
Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G. Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M. Jorge Cardoso, Ana Carvalho, Jessica Collins, Enrico De Vita, John C. Dickson, Norah Epie, Miklos Espak, Susie M. D. Henley, Chandrashekar Hoskote, Michael Hutel, Jana Klimova, Ian B. Malone, Pawel Markiewicz, Andrew Melbourne, Marc Modat, Anette Schrag, Sachit Shah, Nikhil Sharma, Carole H. Sudre, David L. Thomas, Andrew Wong, Hui Zhang, John Hardy, Henrik Zetterberg, Sebastien Ourselin, Sebastian J. Crutch, Diana Kuh, Marcus Richards, Nick C. Fox, Jonathan M. Schott
The brain changes that occur at least a decade prior to the onset of symptoms of Alzheimer's disease are critical to scientists' understanding of its development. PET-MRI imaging allows the pathological process underpinning cognitive impairment to be assessed repeatedly and non-invasively.