POLARIS: Polygenic LD‐adjusted risk score approach for set‐based analysis of GWAS data
Emily Baker, Karl Michael Schmidt, Rebecca Sims, Michael C. O'Donovan, Julie Williams, Peter Holmans, Valentina Escott‐Price
Polygenic risk scores (PRSs) are a method to summarize the additive trait variance captured by genetic variants, and can increase the power of set-based analyses by leveraging public genome-wide association studies. This project developed a novel methodology, POLARIS, which extends upon PRS whilst adjusting for linkage disequilibrium between genetic variants.