PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers
Koychev, Ivan, Gunn, Roger N, Firouzian, Azadeh, Lawson, Jennifer, Zamboni, Giovanna, Ridha, Basil, Sahakian, Barbara J, Rowe, James B, Thomas, Alan, Rochester, Lynn, Ffytche, Dominic, Howard, Robert, Zetterberg, Henriki, MacKay, Clare, Lovestone, Simon
This paper compared amyloid and tau pathology markers as acquired from both CSF and PET imaging within a short window of assessment. The data suggests that even in late onset AD, those people that are relatively younger have a dementia driven more by tau than by amyloid pathology whereas those in the oldest old group have a more diverse pathological driver