Moderating lifestyle and psychosocial factors on genetic susceptibility to dementia comorbidities: an MRC dementias platform UK (DPUK) supported study
Catherine M.Calvin1JohnGallacher1Saskia P.Hagenaars2Sarah E.Harris2GailDavies2Catharine R.Gale2Ian J.Deary2
Evidence suggests that certain lifestyle factors moderate the manifestation of genetic susceptibility to complex diseases such as dementia and its co-morbidities. In these conditions multiple genetic loci explain greater variance in risk than a single candidate gene alone. The present study uses a large UK sample to investigate lifestyle and psychosocial factors that may interact with associations between polygenic scores for specific diseases (e.g. obesity, coronary artery disease, type 2 diabetes), and their manifestation in adulthood, with particular attention to sex-specific effects.