Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease
Nicolai Franzmeier , Emrah Düzel , Frank Jessen , Katharina Buerger , Johannes Levin, Marco Duering , Martin Dichgans , Christian Haass , Marc Suárez-Calvet, Anne M Fagan, Katrina Paumier , Tammie Benzinger , Colin L Masters , John C Morris , Robert Perneczky, Daniel Janowitz , Cihan Catak , Steffen Wolfsgruber , Michael Wagner , Stefan TeipelIngo , Ingo Kilimann , Alfredo Ramirez , Martin Rossor , Mathias Jucker , Jasmeer Chhatwal, Annika Spottke , Henning Boecker , Frederic Brosseron , Peter Falkai , Klaus Fliessbach, Michael T Heneka , Christoph Laske , Peter Nestor , Oliver Peters , Manuel Fuentes, Felix Menne , Josef Priller , Eike J Spruth , Christiana Franke , Anja Schneider, Barbara Kofler , Christine Westerteicher , Oliver Speck , Jens Wiltfang , Claudia Bartels, Miguel Ángel , Araque Caballero , Coraline Metzger , Daniel Bittner, Michael Weiner, Jae-Hong Lee , Stephen Salloway, Adrian Danek, Alison Goate , Peter R Schofield, Randall J Bateman , Michael Ewers
The overall aim of this study was to test particular functional brain features that support higher resilience of cognitive performance during the course of Alzheimer’s disease. The current cross-sectional study assessed for the first time a core candidate functional brain substrate underlying higher cognition during the course of Alzheimer’s disease from preclinical to dementia stages of Alzheimer’s disease.