Experimental Medicine 2 – Integration of clinical and cellular phenotypes in the DPUK Deep and Frequent Phenotyping cohort

The team undertaking this project has pioneered the techniques necessary to culture induced pluripotent stem cells (iPSCs) from a group of individuals (the MRC NIHR Deep and Frequent Phenotyping cohort) with very early AD and Mild Cognitive Impairment and use these cells for further studies. Significant cognitive and biological testing has been conducted on the cohort to provide a wealth of data on individuals. The team aim to test whether these iPSC cells can be used as model systems that will replicate the cognitive and biological processes being undertaken in cohort members and hence provide insight into neurodegenerative diseases.