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Using participants from the DIAN study demonstrated that possessing one copy of the brain-derived neurotrophic factor (BDNF) Met 66 allele increased the severity of impairment in episodic memory and hippocampal function in preclinical autosomal dominant Alzheimer’s disease. The work shows that BDNF is important to the preclinical presentation of AD.

More information Original publication


Publication Date





2766 - 2777



Alzheimer’s disease, amyloid-β, tau, dementia, genetics