Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
Christopher A Lane, , Josephine Barnes, , Jennifer M Nicholas, , Carole H Sudre, , David M Cash, , Thomas D Parker,, Ian B Malone, , Kirsty Lu,, Sarah-Naomi James, , Ashvini Keshavan, , Heidi Murray-Smith, , Andrew Wong, , Sarah M Buchanan, , Sarah E Keuss, , Elizabeth Gordon, , William Coath,, Anna Barnes, , John Dickson, , Marc Modat, , David Thomas, , Sebastian J Crutch,, Rebecca Hardy, , Marcus Richards*, , Nick C Fox*, , Jonathan M Schott*
Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated through amyloid or vascular-related mechanisms are poorly understood. We aimed to identify if, and when, blood pressure or change in blood pressure during adulthood were associated with late-life brain structure, pathology, and cognition.