Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
Christopher A Lane, PhD, Josephine Barnes, PhD, Jennifer M Nicholas, PhD, Carole H Sudre, PhD, David M Cash, PhD, Thomas D Parker, PhD, Ian B Malone, PhD, Kirsty Lu, MA, Sarah-Naomi James, PhD, Ashvini Keshavan, MRCP, Heidi Murray-Smith, MSc, Andrew Wong, PhD, Sarah M Buchanan, FRACP, Sarah E Keuss, MRCP, Elizabeth Gordon, MSc, William Coath, MSc, Anna Barnes, PhD, John Dickson, PhD, Marc Modat, PhD, David Thomas, PhD, Prof Sebastian J Crutch, PhD, Prof Rebecca Hardy, PhD, Prof Marcus Richards, PhD †, Prof Nick C Fox, FMedSci †, Prof Jonathan M Schott, FRCP
Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated through amyloid or vascular-related mechanisms are poorly understood. We aimed to identify if, and when, blood pressure or change in blood pressure during adulthood were associated with late-life brain structure, pathology, and cognition.