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This study suggests that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment. The effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks.

Original publication

DOI

10.1038/s41380-019-0404-6

Type

Journal article

Publisher

Molecular Psychiatry

Publication Date

21/03/2019

Addresses

https://www.nature.com/articles/s41380-019-0404-6#Sec1

Keywords

Alzheimer’s disease, beta-amyloid