We aimed to characterise where in the brain and when in the course of the disease neuroimaging biomarkers become abnormal. Findings suggesting differential regional and temporal vulnerabilities to Aβ, metabolic decline, and structural atrophy, which should be taken into account when using biomarkers in a clinical setting as well as designing and evaluating clinical trials.
We aimed to characterise where in the brain and when in the course of the disease neuroimaging biomarkers become abnormal. Findings suggesting differential regional and temporal vulnerabilities to Aβ, metabolic decline, and structural atrophy, which should be taken into account when using biomarkers in a clinical setting as well as designing and evaluating clinical trials.