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This study demonstrated a voxel-level correlation between [11C]BU99008 PET measuring astroglial metabolism consistent with astroglial activation and glucose metabolism in patients with AD/MCI subjects. The demonstration of positive and negative correlation between astroglial activation and cerebral glucose metabolism suggested that astroglial activation is heterogeneous across the AD brain.

Original publication

DOI

10.1016/j.jalz.2018.06.2999Get

Type

Journal article

Publication Date

07/2018

Volume

14

Addresses

https://www.sciencedirect.com/science/article/pii/S1552526018331777?via%3Dihub

Keywords

A[11C]BU99008 PET, [18F]FDG and [18F]Florbetaben PET, ALZHEIMER’S DISEASE, neurodegenerative disease , mitochondrial membranes, glucose metabolism, amyloid