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Polygenic risk scores (PRSs) are a method to summarize the additive trait variance captured by genetic variants, and can increase the power of set-based analyses by leveraging public genome-wide association studies. This project developed a novel methodology, POLARIS, which extends upon PRS whilst adjusting for linkage disequilibrium between genetic variants.

Original publication

DOI

10.1002/gepi.22117

Type

Journal article

Publication Date

06/2018

Volume

4

Pages

366 - 377

Addresses

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001515/

Keywords

genetics, GWAS, linkage disequilibrium, MAGMA, polygenic risk score