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This paper describes a robust method to derive microglia from human pluripotent stem calls. These microglia were used to study the consequences of missence mutations of the TREM2 receptor implicated in frontotemporal dementia-like syndrome and Nasu- Hakola disease (NHD). The work demonstrated there is a complex and subtle effect of missense TREM2 mutations on microglial function that could be consistent with the delayed clinical symptoms seen in FTD-like syndrome and NHD.

More information Original publication

DOI

https://doi.org/10.1016/j.stemcr.2018.03.003

Type

Journal article

Publisher

Elsevier

Publication Date

04/2018

Volume

10

Pages

1294 - 1307

Addresses

https://www.sciencedirect.com/science/article/pii/S2213671118301097?via%3Dihub

Keywords

dementia , microglia, TREM2, Nasu-Hakola disease, frontotemporal dementia, iPSC-microglia, neuroinflammation