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This study confirmed the potential of the [11C]BU99008 PET tracer to detect differences in astroglial metabolism consistent with activation between healthy volunteers and people with AD. The higher uptake in the amyloid positive population compared to the amyloid positive and the HCs is consistent with recognised roles for astrocyte activation in AD, e.g., for clearing Aβ deposition.

Original publication

DOI

10.1016/j.jalz.2018.06.1072

Type

Journal article

Publisher

Elsevier

Publication Date

07/2018

Volume

14

Pages

842 - 843

Addresses

https://www.sciencedirect.com/science/article/pii/S1552526018312445?via%3Dihub

Keywords

astroglial metabolism, amyloid positive, amyloid negative