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How DPUK is adapting to rapid change
Publications
Researchers at DPUK and other institutions worldwide have published articles based on their work using DPUK resources. Here we list a wide selection of research papers that have either been funded or enabled by DPUK. You can search by author and topic.
Clinical Studies Register
Our Clinical Studies Register comprises more than 58,000 research participants who have already undergone extensive characterisation and have pre-existing consent for re-contact through their parent DPUK cohort.
Great Minds
Great Minds is a register of over 13,000 highly characterised research volunteers. It is a resource available for researchers enabling precision-matching for studies.
DPUK Datathons
DPUK Datathons are FREE ONLINE EVENTS. They are a key part of our data analyst training programme, placing researchers in multidisciplinary teams to generate valuable new findings in dementia research using cohorts in the DPUK Data Portal.
Deep and Frequent Phenotyping
The Deep and Frequent Phenotyping study has been described as one of the most significant current areas of research in dementia.
TDF Register Volunteers
The DPUK Trials Delivery Framework Register serves as a national repository of valuable information, including memory scores, clinical history, brain scan results, and medications, collected from local research registers at patients' local sites. By agreeing to place their data in the Register, individuals gain the opportunity to be contacted for future research studies within the Trials Delivery Framework that align with their suitability.
IMPRINT & IMPACT
The Immune Profiling in Early Cognitive Disorders (IMPRINT) study investigates the role of neuroinflammation in the onset and progression of neurodegenerative diseases including Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Inflammation is the process by which the immune system (white blood cells and other proteins) work to protect the body from things that may harm it. Whilst this is an important process to protect the body, in some instances the inflammation itself can be too extreme or continue for too long and then actually be harmful rather than helpful. Neuroinflammation (inflammation in the brain) has long been associated with dementia, as immune cells work to clean up proteins which build up in the brains of those affected by the condition. There now exists increasing evidence that the immune system, through
NTAD & SHINE
The Synaptic Health theme of Dementias Platform UK, aims to understand how synaptic changes lead to cognitive impairment; and how these differences can best be measured in humans and used to support early interventions in neurodegenerative diseases. Two studies have been undertaken. NTAD (which has now been completed) & SHINE (a current study which began in 2023).
READ-OUT
READ-OUT is one of 2 £4.5 million studies which are part of the Blood Biomarker Challenge, a project run by the Alzheimer’s Society, Alzheimer’s Research UK. Its funding comes from the National Institute for Health and Care Research and Gates Ventures as well as £5m raised by players of People’s Postcode Lottery. The project aims to revolutionise dementia diagnosis. READ-OUT is undertaking broad, nationwide blood sampling at 29 sites across the UK to understand which biomarkers perform the best in diagnosing Alzheimer’s and non-Alzheimer's dementias.
FAST Study
The FAST (Feasibility and Acceptability of Scalable Tests) study is a pilot research study run by Dr. Ivan Koychev at University of Oxford and Dementias Platform UK. The study is assessing attitudes to dementia risk screening using digital and blood tests. It will lead to a far larger nationwide study investigating blood biomarkers for brain health across Britain, particularly markers for dementia and memory disorders.