Integrating clinical and cellular features of dementia
The Deep and Frequent Phenotyping (DFP) study will be almost certainly the most extensively assessed cohort of people with very early Alzheimer’s disease and mild cognitive impairment. This is a DPUK-funded study led by Richard Wade-Martins, University of Oxford.
All participants will have at baseline very extensive clinical and biological assessments, including detailed cognitive measures and biological measures of pathology: both amyloid and tau PET, and molecular assays of both of these in the cerebrospinal fluid. All participants are approached for consent to donate cells for iPSC stem cell generation, and all give consent for follow up from electronic health records and other linked data.
The hypothesis to be tested is that the cellular phenotype (what the cells looks like) of iPSC-derived neurons from patients will reflect the clinical phenotyping using an extensively ‘deep phenotyped’ Alzheimer’s cohort.