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  • Looking for the blood-based signs of cognitive decline

    Testing potential biological signs, known as 'biomarkers', of cognitive ability in late life is of interest for both theory and practice in dementia research. This is a DPUK funded study, led by Ian Deary at the University of Edinburgh.

  • Integrating clinical and cellular features of dementia

    The Deep and Frequent Phenotyping (DFP) study will be almost certainly the most extensively assessed cohort of people with very early Alzheimer’s disease and mild cognitive impairment. This is a DPUK-funded study led by Richard Wade-Martins, University of Oxford.

  • Deep and Frequent Phenotyping Study

    One of the principal challenges for the dementia research community worldwide is how we can study the brain in the very early stages of the disease. This is a study within DPUK, led by Simon Lovestone, University of Oxford.

  • A closer look at ‘glial’ cells and their role in Alzheimer’s disease

    This team is using a range of different imaging techniques to undertake a proof-of-concept study to test if PET scans can provide useful information about 'glial cells' – an important helper cell in the brain. The degeneration of glial cells may have a role in the development of Alzheimer’s disease. This is a DPUK-funded study led by Paul Matthews at Imperial College London.

  • Crosstalk: the impact of cardiac anatomy and function on brain structure and health

    The brain and the heart are the two organs which have been studied more than any other, providing a profound, though still incomplete, understanding of ageing and the development of disease. This is a DPUK funded study, led by Steve Williams at King’s College London.

  • New Therapeutics in Alzheimer’s Disease

    Scientists are looking to find out whether MEG scans which measure the electrical activity in the brain can be used to detect some of the very earliest signs of Alzheimer's disease: the loss of connections between the neurons in the brain.

  • Rates, Risks and Routes to Reduce Vascular Dementia

    Stroke commonly affects cognition, and vascular dementia is driven by stroke disease in some way. This is a multi-funder study led by Joanna Wardlaw at the University of Edinburgh.