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Selective recruitment of high-risk participants into clinical trials for dementia research is both cost effective and highly informative.

Identifying subgroups of individuals who are at high risk of cognitive decline in the short to medium term or is important for informing recruitment into clinical trials and clinical decision-making. As part of the DPUK project, this study aims to develop and apply state-of-the-art risk stratification methods to identify such subgroups in DPUK cohorts.

The impact of this work is important for informing highly specific recruitment into clinical trials.