Oxford Parkinson Disease Centre Discovery Cohort
Principal Investigator: Dr Michele Hu
Start date: 2009
Age at recruitment: 18+
Sample size at recruitment: 1,082 PD, controls 297, 106 PD relatives, 104 RBD
Oxford Parkinson Disease Centre (OPDC) was established in 2009 with funding from the Parkinson UK Monument Discovery Award. It brings together world-leaders in clinical neurology, neuroepidemiology, neuroimaging, proteomics, genomics, molecular genetics, transgenic PD models, neuropharmacology, neurophysiology and neuropathology. The OPDC Discovery cohort is a prospective, longitudinal study that has recruited patients with early idiopathic Parkinson Disease, healthy controls and participants at risk of PD. The study also includes participants with REM Sleep Behaviour Disorder.
Oxford University Department of Clinical Neurology
West Wing Level 3
John Radcliffe Hospital
Funders (core support):
Parkinson UK Monument Discovery Award
Anthropometric and physical: height; weight; blood pressure; cardiovascular; respiratory; hearing and vision.
Psychological: cognitive function; mental health.
Lifestyle: smoking; alcohol; dietary habits.
Socio-economic: education; occupation.
Brain imaging: MRI.
Biological Samples: blood; other.
This cohort was funded by the Monument Trust Discovery Award from Parkinson’s UK and supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust and University of Oxford, and the NIHR Clinical Research Network: Thames Valley and South Midlands.