The Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation-PD
Principal Investigator: Professor David Burn
Start date: 2009
Age at recruitment: 18+
Sample size at recruitment: 219 with PD and 99 controls (318 total)
Estimated current sample size: 219 with PD and 99 controls (318 total)
The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonism in Newcastle-Gateshead and Cambridgeshire. A key objective is to identify patients who develop Parkinson’s disease dementia (PDD) and the factors that predict its evolution. From this information, a simplified panel of tests that can be used to predict PDD will be established. ICICLE-PD will therefore provide a platform for studies investigating agents designed to help treat this complication of PD. Participants were recruited between June 2009 and March 2012. Longitudinal follow up is on going with assessments at 18-month intervals.
Clinical Ageing Research Unit
Campus for Ageing and Vitality
Newcastle upon Tyne
Funders (core support):
Parkinson’s Disease Society
Rhoda Lockhart Parkinson’s Disease Research Fund
Anthropometric and physical: height; weight; blood pressure; cardiovascular; hearing; vision.
Psychological: cognitive function; mental health.
Lifestyle: smoking; alcohol; physical activity.
Socio-economic: education; occupation; employment.
Brain imaging: MRI; PET.
Biological Samples: blood; other.
Acknowledgement statement: This work was funded by grants from Parkinson’s UK (J-0802) and Lockhart Parkinson’s Disease Research Fund. The research was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Unit based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University and a NIHR Biomedical Research Centre award to the University of Cambridge/Addenbrooke’s Hospital.