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PI: Professor David Porteous

Start date: 2006

Age at recruitment: 18+

Sample size at recruitment: 24,090

Estimated current sample size: 24,090

The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas with current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland. DNA and non-identifiable information from this cohort will be made available to researchers in Scotland and international collaborators. GS:SFHS also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 3,000 GS participants have been invited for scanning.

Originally, the study recruited probands and their family members. Recruitment ended 10/05/2011. Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17.


Contact details:

Medical Genetics Section
University of Edinburgh
Molecular Medicine Centre
Western General Hospital
Crewe Road South

Funders (core support):

Scottish Government Chief Scientist Office with genotyping funded by MRC & Wellcome Trust. Currently funded from NHS Lothian. 

Gender: MF

Variables collected:

Anthropometric and physical: height; weight; waist circumference; hip circumference; blood pressure.

Psychological: mental health; cognitive function.

Lifestyle: smoking; dietary habits; alcohol.

Socio-economic: occupation; education.

Biological samples: blood; urine.

Brain imaging: MRI (only those in the STRADL study).

Acknowledgement statement: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Ethical approval for the GS:SFHS study was obtained from the Tayside Committee on Medical Research Ethics ( 05/S1401/89 Tayside Committee on Medical Research Ethics A). We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the whole Generation Scotland team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants and nurses.