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Principal Investigator: Professor Carol Brayne

Start date: 2008

Age at recruitment: 65>

Sample size at recruitment: 7,524

Estimated current sample size: 7,524

CFAS II is based in England and Wales started in 2008, and builds on the design and infrastructure of MRC CFAS. CFAS II provides data on generational and geographical differences, including people in institutions. It also provides important base-line information on older people aged 65-84 in 2007-2008 who will reach the age of greatest frailty during the 2020s when the peak in the number of people aged 85 or over is expected and at a time when major therapeutic interventions for dementia could be expected to have an effect.


Contact details:

Institute of Public Health
Forvie Site
University of Cambridge School of Clinical Medicine
Box 113 Cambridge Biomedical Campus

01223 330312

Funders (core support): Medical Research Council

Gender: MF

Variables collected:

Anthropometric and physical: cardiovascular; respiratory; hearing; vision.

Psychological: mental health; cognitive function.

Lifestyle: smoking; physical activity; dietary habits; alcohol.

Socio-economic: education; occupation.

Biological samples: saliva; other (buccal cell placenta, brain, muscle, teeth, hair).

Acknowledgement statement:

CFAS II has been supported by a major award from the UK Medical Research council (G0601022) and received support from the National Institute for Health Research (NIHR) comprehensive clinical research networks in West Anglia and Trent, and the Dementias and Neurodegenerative disease research network (DeNDRoN) in Newcastle. The UK National Institute of Health Research collaboration for leadership in applied health research for Cambridgeshire and Peterborough (CLAHRC EoE) and the Cambridge Biomedical Research Centre infrastructures. Nottingham City and Nottingham County NHS primary care trusts and the UK NIHR biomedical research centre for ageing and age-related disease award to Newcastle upon Tyne hospital foundation trust.

We would like to thank the participants, their families, general practitioners and their staff and the primary care trusts for their cooperation and support. We are most grateful to the CFAS fieldwork Interviewers and administration staff based at Cambridge, Newcastle and Nottingham for their valuable contribution to the study.

Ethical approval for the CFAS II study was given by Cambridgeshire 4 Research Ethics Committee 07/MRE05/48.