Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease
E. McDade, G. Wang, B.A. Gordon, J. Hassenstab, T.L.S. Benzinger, V. Buckles, A.M. Fagan, M. Holtzman, N.J. Cairns, A.M. Goate, D.S. Marcus, J.C. Morris, K. Paumier, C. Xiong, R. Allegri, S.B. Berman, W. Klunk, J. Noble, J. Ringman, B. Ghetti, M. Farlow, R.A. Sperling, J. Chhatwal, S. Salloway, N.R. Graff-Radford, P.R. Schofield, C. Masters, M.N. Rossor, N.C. Fox, J. Levin, M. Jucker, R.J. Bateman
Paper aims to assess the onset, sequence, and rate of progression of comprehensive biomarker and clinical measures across the spectrum of Alzheimer disease (AD) using the Dominantly Inherited Alzheimer Network (DIAN) study. It clarified the sequence and temporal dynamics of presymptomatic pathologic changes in autosomal dominant AD, information critical to a better understanding of the disease.