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Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated through amyloid or vascular-related mechanisms are poorly understood. We aimed to identify if, and when, blood pressure or change in blood pressure during adulthood were associated with late-life brain structure, pathology, and cognition.

Original publication

DOI

10.1016/S1474-4422(19)30228-5

Type

Journal article

Publisher

Lancet

Publication Date

08/2019

Pages

942 - 952

Addresses

https://www.thelancet.com/action/showPdf?pii=S1474-4422%2819%2930228-5

Keywords

blood pressure , late-life brain structure, pathology in the neuroscience, 1946 British birth cohort (Insight 46)