DPUK is working with the Principal Investigators of over 45 cohort studies, bringing together a wide variety of data for dementia researchers.
Case-rich population cohorts
These large population-based studies have followed adults into their seventies, eighties, and some beyond – a stage in life when the risk of dementia substantively increases in the population. These collective studies provide sufficient case numbers of dementia with which to better characterise risk and protective factors associated with the dementias, as well as to study trajectories of disease progression.
Prodromal population cohorts
These large population-based studies are following adults in their forties and fifties, before clinical symptoms of dementia appear in the majority of cases. This stage of life is critical for understanding the multiple risk and protective factors that contribute to onset of dementia, given the long preclinical (prodromal) phase of dementia, and to study disease progression in its early stages.
Dementia case cohorts
Dementia case cohorts involve the study of patients with a diagnosis of dementia or related neurodegenerative disease. They often involve frequent follow-up and extensive assessment of individuals, in order to characterise the progression of disease pathology and/or clinical symptoms, or, to understand the care needs of individuals and their families. Many of the studies involve a healthy control group of participants.
Genetic risk cohorts
Genetic risk cohorts include individuals who carry genetic mutations that increase their risk of specific dementias or a closely related neurodegenerative disease, ie Parkinson’s and Huntington’s diseases. Disease onset and progression is followed up by cognitive and neuropsychiatric assessment, and by measuring clinical features, disease biomarkers, and neuropathology.
Find out more about the data collected by cohort studies that are collaborating with DPUK in the cohort matrix.