Researchers are using samples from the Deep and Frequent phenotyping study pilot to prepare 'induced pluripotent stem cells' for investigating some of the earliest changes in Alzheimer's disease.
DPUK enabled experimental medicine Impact Trials
The New Therapeutics into Alzheimer's Disease (NTAD) study is looking to detect markers of the disease before symptoms show. These markers for the disease will be used to test whether experimental treatments can delay, or even prevent, the progression of the disease.
Researchers conducting the biggest study in the Data Portal are looking into how early experiences of adversity impact brain health right across the lifespan.
DPUK enabled experimental medicine Imaging
One of the big challenges facing dementia researchers is how to diagnose and track Alzheimer’s disease in its earliest stages – often decades before symptoms start to show. The Deep and Frequent Phenotyping study will help scientists to identify the best early warning signs of this condition, and to track responses to treatments.
DPUK aims to deliver breakthroughs in dementia research through experimental medicine studies. We both directly fund and enable these studies through our technology infrastructure. In many cases, they will recruit through our clinical studies register.
Dementias Platform UK focuses on a wide range of areas, assessing and improving the cohort and data resources for dementia research.
Imaging Stem cells
Scientists are studying neurodegenerative disease using stem cells derived from the blood samples of cohort study participants. These cells - iPSCs - are a valuable resource.
Impact Stem cells
Scientists are repurposing the drug libraries of AstraZeneca (AZ) on patient-specific cell models. Can they be used for diseases like Alzheimer's and Parkinson's diseases?
Bringing together cognitive, lifestyle, genetic, biomedical, demographic and psychosocial data will allow researchers to identify the key factors that allow people to live well – without developing dementia.
By collaborating with industry partners, DPUK cohorts can access cognitive test technologies to enhance their studies. Computer-adaptive techniques and cloud-based platforms brings industry technology within reach.
Participants in DPUK's cohorts, will be offered the chance to join DPUK's Great Minds register.
Many studies indicate that there may be links between heart health and brain health, and this connection may be a promising new avenue in research and development for treatments for brain diseases. DPUK-funded researchers on the Crosstalk study are using large imaging datasets to look for early indicators of brain changes that show up in other organs too.
A DPUK ECR grant winner's research into the links between our environment and brain health has been used to inform a forthcoming World Health Organisation (WHO) report on healthy ageing.