Case studies

Great Minds coming together

Ivan Koychev, Great Minds lead and Clinical Scientist at Dementias Platform UK (DPUK), describes an exciting new chapter in dementia research which, with the support of generous new members of Great Minds, promises to accelerate the development of innovative new treatments.

Study into early Alzheimer's disease treatments

The New Therapeutics into Alzheimer's Disease (NTAD) study is looking to detect markers of the disease before symptoms show. These markers for the disease will be used to test whether experimental treatments can delay, or even prevent, the progression of the disease.

Study volunteer Gillian Brown talks to trial co-ordinator Tony Thayanandan.

Deep and Frequent Phenotyping study

One of the big challenges facing dementia researchers is how to diagnose and track Alzheimer’s disease in its earliest stages – often decades before symptoms start to show. The Deep and Frequent Phenotyping study will help scientists to identify the best early warning signs of this condition, and to track responses to treatments.

Cell studies of early Alzheimer's disease

Researchers are using samples from the Deep and Frequent phenotyping study pilot to prepare 'induced pluripotent stem cells' for investigating some of the earliest changes in Alzheimer's disease.

Case studies and experimental medicine

The ambition of DPUK is to bring multidisciplinary teams together in collaborations that produce groundbreaking research. By working together, industry, health technology experts, data analysts, and dementia researchers are able to innovate dementia studies.

By working together DPUK's research networks have broken down traditional barriers and nurtured new talent and opportunities. One partnership is investigating repurposing of the drug libraries of AstraZeneca (AZ) for patient-specific cell models.

Another collaboration has created the world's first national brain imaging network capable of aligning results from different imaging centres. Such technological expertise allows researchers to investigate the early causes of degenerative brain disease - before symptoms show.

Case studies

Stem cell

Stem cell studies

Experimental medicine

Other studies

More DPUK studies

Transforming clinical studies

Find out why cohort participants are being offered the chance to join the Great Minds register and contribute to dementia studies.

Clinical studies

Studies in the Data Portal

One research programme in the Data Portal is looking into childhood experiences of adversity and brain health in later life.

Cohort studies