Amyloid is a brain protein which is associated with dementia, but it is difficult and expensive to detect. This team is conducting brain scans on 500 men and women who are already members of a long-term health study. Their extremely valuable data will be used to develop new, more convenient ways of testing for amyloid in the brain.
Some of the diseases that cause dementia have a genetic element. Looking at familial disease dementia is important because those genetically predisposed to dementia can be analysed for indicators that can then be used to improve our understanding of the other forms of the disease.
Uncovering the biological signs of change that are associated with the development of Alzheimer's disease is a crucial part of detecting it at its earliest stages and developing effective treatments.
Scanning 10,000 participants a few years after a baseline scan allows for very informative findings about how our brains change as they get older.
This early area of work identified which long-term studies of health – known as 'cohorts' – would be particularly helpful for dementia research, and summarised their information for researchers’ use on the Data Portal.