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Bryan conducts studies of the development of disease in dish, enabling a very close study of the living brain cells known as 'cortical neurons' outside living organisms.
Bryan could not do this work without the important contributions of a number of other scientists – and the original study participants. His work is just one stage in a wider research effort.
1. Recruitment of study volunteers – participants in this study were carefully selected by Simon Lovestone’s team. Research staff took blood tests and skin samples.
2. The samples were sent to Zam Cadar at the University of Oxford. The team reprogrammed the blood cells to become induced pluripotent stem cells (IPSCs).
3. The iPSCs were sent to Bryan at the University of Oxford.