Researchers took skin samples from healthy volunteers and patients diagnosed with Alzheimer's or Parkinson's disease. They then undertook processes known as reprogramming to cause them to become iPSC stem cells.
Scientists are able to modify genetic code and investigate the effects in induced pluripotent stem cells (iPSCs) – living cells derived from human skin and blood. Research teams in Oxford, Cardiff and Edinburgh are working in this area.
Using the iPSC stem cells, many groups in the Stem Cells Network are focused on the development of several types of brain cells via a complex set of processes known as 'differentiation'.
Using state-of-the-art equipment and the newly developed iPSC stem cell resource, scientists are investigating the behaviour of industry-developed drugs in new contexts.