Dementia is a global health problem for which there is no disease modifying therapy. Encouragingly, several population-based cohort studies have reported a ‘declining’ incidence of dementia in the UK, US and European countries.
Vascular factors such as hypertension are suspected as major determinants of this trend. However the evidence for this is inconclusive as estimates for the impact of vascular factors on the declining incidence of dementia varies widely between studies, ranging from ‘no significant modification’ (Satizabal et al, 2016) to ‘accounting for about 25%’ (Ahmadi-Abhari et al, 2017). Filling this knowledge gap is critical to the development of public health based dementia prevention strategies.