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Predictors of successful ageing in European superagers


Successful brain function in the very old (90+ years) may inform understanding of how to maintain healthy brain function across the lifespan. Researchers will develop a derived 90+ dataset for continued population research.

Identifying sub-groups of individuals who are at risk of cognitive decline

Selective recruitment of high-risk participants into clinical trials for dementia research is both cost effective and highly informative. This work will help inform highly specific recruitment to clinical trials of dementia treatments.

Using longitudinal data for predicting Alzheimer’s disease

Understanding the predictors of Alzheimer’s disease will aid early diagnosis. Researchers will use machine learning techniques with DPUK cohorts to support the efficient design of clinical trials.

Big data for precision medicine

Unified sources of data from cohort studies will aid diagnosis and treatment of dementia.

Longitudinal relationships between mental health and cognitive change

We know from previous studies that poor mental health can have a harmful effect on cognitive function in old age. In this study we are using the existing mental health and cognitive data in five cohorts to examine anxiety, depression and stress.

Prevail Parkinson's Disease natural history

Prevail Therapeutics is a biotech company that is developing gene-therapy for brain disorders such as Parkinson's disease. The researchers are using the Data Portal to investigate the genetics of the disease.

The effects of cholinesterase inhibitors in dementia due to Alzheimer's disease

There is increased evidence of beneficial, though modest, effects from clinical trials for three drugs which are acetylcholinesterase inhibitors (AcEIs). The aim of the study is to enrich the evidence on AcEIs by looking at their effectiveness in more realistic settings.

Associations between hormones, mental health and cognition

The sex-hormones testosterone and oestrogen are implicated in psychological behaviour and as such, also in psychiatric disorders. This study will explore hormone levels and cognitive performance to investigate the associations and interactions in these variables.

Childhood adversity and mental health in later life

Sexual abuse, deprivation and family dysfunction are traumatic events which some children live through, and which are known to be linked to mental health in adulthood. Researchers are exploring these associations across four DPUK cohorts in the Data Portal.

Brains for dementia research

Researchers have curated the genetic datasets relating to the donated brains in the Brains for Dementia Research cohort study.

Investigating the associations between early adult activities and later life cognition

This study will conduct many individual analyses to investigate associations between lifestyle activities, physical fitness, social engagement, biomedical measures and mental health on later life cognition

Harmonising large imaging databses to assess white matter tissue hyperintensities in cognitive ageing

This study aims to develop and refine tools for harmonising measurements of white matter hyperintensities in existing DPUK cohorts.

Metabolic and cardiovascular disease and treatments in cognitive decline

Cardiovascular and metabolic diseases impact organs and tissues beyond those of the cardiovascular system. However, despite the social burden, the causative mechanisms are still poorly understood.

Body Mass Index and cognitive function

Research suggests higher Body Mass Index (BMI) in midlife is associated with lower cognitive function in later life. However, this association is not found to be consistently observed across age groups.

Assessing individual differences in cognitive change over time

Assessing the trajectory of cognitive change over time is of utmost importance in the pursuit of understanding cognitive ageing and dementia. In this study we assess datasets with detailed longitudinal cognitive records.

Have we overestimated the impact of vascular factors on the declining incidence of dementia?

The impact of vascular factors on the declining incidence of dementia varies widely between studies. Filling this knowledge gap is critical to the development of public health based dementia prevention strategies.

The effects of mental health status on dementia progression in the Whitehall II cohort

It is well established that psychiatric symptoms are associated with cognitive decline and neural degeneration in older age. This study aims to evaluate in more detail the nature of the associations.

Validating disease progression models using real world data

Disease models which use ‘real world data’ from existing population cohorts can be used to improve efficiency of drug treatment strategies.

DPUK data discovery tools categorisation and coding programme

Dementias Platform UK (DPUK) proposes to develop its own data discovery tools so that data can be highly categorised, enabling researchers to more clearly identify cohorts which are applicable for their research proposals.

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