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White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
The major goal of this study was to close the research gap of the integration of white matter changes within standard biomarker models of the pathological ...
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BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
Using participants from the DIAN study demonstrated that possessing one copy of the brain-derived neurotrophic factor (BDNF) Met 66 allele increased the ...
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Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease
The overall aim of this study was to test particular functional brain features that support higher resilience of cognitive performance during the course of ...
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The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease
This study suggests that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, ...
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Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease
Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a ...