Polygenic risk of Alzheimer's disease and neurodegenerative related traits and their association with cognitive function: UK Biobank and The Dementias Platform UK
Chloe Fawns-Ritchie, Saskia P.Hagenaars, Sarah E.Harris, GailDavies, David C.Liewald, W. David Hill, Jill P.Pell, John Gallacher, Daniel J.Smith , Catharine R.Gale, Ian J.Deary
Genome-wide association studies have identified a number of genes which are associated with increased risk of developing Alzheimer's disease, a disease characterised by progressive decline in cognitive abilities, including episodic memory and executive functioning. In ageing, scores on cognitive tests vary substantially within the population and there may be shared genetic aetiology between cognitive functions and neurodegenerative diseases. Here, the association between polygenic profile scores for Alzheimer's disease, as well as measures associated to neurodegeneration, and cognitive function was investigated.