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Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD) is associated with cognitive function and physical health in the UK Biobank, a cohort of healthy individuals.

More information Original publication

DOI

10.1371/journal.pone.0198187

Type

Journal article

Publication Date

01/06/2018

Keywords

neurodegenerative disorders, Genetic risk, cognitive ability, physical function